If you hit the error message when running the DotNetNuke installation wizard:
————————————————————————————————————————–
Exception Details: System.Security.SecurityException: Request for the permission of type ‘System.Web.AspNetHostingPermission, System, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089′ failed.
Source Error:
An unhandled exception was generated during the execution of the current web request. Information regarding the origin and location of the exception can be identified using the exception stack trace below.
————————————————————————————————————————–
Set the Application Pool of IIS to ASP.NET v4.0 by following Server Error – Configuration Error – IIS ASP.NET 4.
Hope you will not find another error beside this one.