When you want to connect to VPN network using Cisco AnyConnect VPN Client then you receive an error message “Failed to initialize connection subsystem”.
To fix it.
1. Run RegEdit.exe (normally located in C:\Windows folder).
2. Access to HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Internet Settings.
3. Add Key, GlobalUserOffline.
4. There will be only one entry named (Default). Set the (Default) value to 1.